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Nanda, Smiti
- Comparative Study of Nifedipine and Terbutaline as Tocolytic Agents in the Management of Preterm Labour
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Authors
Affiliations
1 General Hospital, Rohtak, Haryana, IN
2 PGIMS, Rohtak, Haryana, IN
3 SDM College of Pharmacy, Kaithal, Haryana, IN
1 General Hospital, Rohtak, Haryana, IN
2 PGIMS, Rohtak, Haryana, IN
3 SDM College of Pharmacy, Kaithal, Haryana, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 5, No 4 (2013), Pagination: 232-236Abstract
The aim of this study was to compare the effectiveness, safety and possible adverse effects of terbutaline and nifedipine in prolonging pregnancy beyond 48 hrs. A randomized controlled trial was conducted with 60 pregnant women admitted with preterm labor, randomized into two groups, which were given terbutaline (30 patients) and nifedipine (30 patients) respectively. Bivariate and multivariate analysis, using regression, were used to analyze the data. No statistically significant difference was found between the two groups in terms of prolongation of gestation to 48 hrs. Both the drugs significantly prolonged the pregnancy (P < 0.001), however there was no statistically significant (P > 0.05) difference in the tocolytic efficacy (mean absolute prolongation of gestation) and birth outcomes between the two groups. The maximum number of patients in both groups (47 % in group A and 70 % in group B) delivered between 34.1 to 37 weeks. However, side effects were significantly more common in the terbutaline group (P < 0.02), especially maternal tachycardia, transient hypotension and chest pain. In the terbutaline group, 14.8 % neonates required mechanical ventilation while 11.1 % suffered intra ventricular hemorrhage. Terbutaline and nifedipine appeared to be equally effective in their tocolytic action. However, nifedipine did have the advantage of the ease of administration. It also had significantly less side effects.Keywords
Terbutaline, Nifedipine, Preterm Labor and Tocolysis
References
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- A Comparative Study of Paracetamol and Tramadol in Hysterectomy Patients
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Authors
Affiliations
1 Department of Obstetrics and Gynaecology, Pt. B. D. Sharma PGIMS, Rohtak, Haryana, IN
2 Department of Obstetrics and Gynaecology, Pt. B. D. Sharma PGIMS, Rohtak - 124001, Haryana, IN
3 Department of Obstetrics and Gynaecology, University College of Medical Sciences, New Delhi, IN
1 Department of Obstetrics and Gynaecology, Pt. B. D. Sharma PGIMS, Rohtak, Haryana, IN
2 Department of Obstetrics and Gynaecology, Pt. B. D. Sharma PGIMS, Rohtak - 124001, Haryana, IN
3 Department of Obstetrics and Gynaecology, University College of Medical Sciences, New Delhi, IN
Source
The Indian Practitioner, Vol 74, No 8 (2021), Pagination: 17-21Abstract
Aim: To compare the efficacy and side effects of paracetamol and tramadol infusion for postoperative analgesia after elective hysterectomy.
Materials and Methods: The present prospective study was conducted on 50 patients who underwent elective hysterectomy in a tertiary care hospital. The patients were divided into two groups. Group A received paracetamol (PCM) infusion, while group B received tramadol infusion. The analgesic efficacy of both the drugs was assessed by Visual Analogue Scale (VAS) at 15, 30 minutes, 1, 2, 4, 6 and 8 hours. The side effects were noted and compared. The records of all the parameters were maintained as per patient proforma.
Results: Both the groups were comparable with respect to demographic profile, duration and route of surgery. The pvalues for the VAS score at 15 min, 30 min, 1 hr, 6 hrs and 8 hrs were insignificant in both the groups. Although pain relief at two and four hours was better in patients of hysterectomy who received tramadol as compared to the patients who received paracetamol, additional analgesia was not required in most of the patients. The number of patients who experienced nauseavomiting (32%), sedation (20%) and headache (12%) were more in the tramadol group.
Conclusion: The present study demonstrates that PCM and tramadol has comparable analgesic effect. At the same time PCM has emerged as a safer analgesic in comparison to tramadol because of its fewer side effects.
Keywords
Paracetamol, Tramadol, Postoperative, Analgesia, Hysterectomy.References
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